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Vigilance over early weight loss on HIV treatment needed, Tanzanian study shows
Carole Leach-Lemens, 2012-01-18 17:10:00
Nearly one-third of patients experienced substantial weight loss in the first ten months after starting antiretroviral therapy, leading American and Tanzanian researchers to warn that health care workers in resource-limited settings need to be on the look out for the ill effects of anaemia, malabsorption and malnutrition in patients starting antiretroviral therapy.
Three months after starting ART the median weight gain among 19,000 HIV-infected adults in Dar es Salaam, Tanzania was 2.5 kg (IQR:0.2-5.0) yet close to 4,000 (21%) lost weight, and 1,520 (8%) had a significant weight loss (greater than or equal to 5% of their weight) researchers report in the advance online edition of AIDS.
Those who were underweight at the start of ART were less likely to lose weight than those of normal or above-average weight, and gained the most weight after starting treatment (a mean of 10kg in the first year, compared to 3kg for patients who were classified as obese).
Baseline symptoms including loss of appetite, nausea and/or vomiting, and difficulty breathing were all independent predictors of weight loss three months after starting ART in this cross-sectional and longitudinal analysis.
Lower socio-economic status and being younger or older than those aged 30 to 49 were associated with a higher risk of long-term significant weight loss while being female had a lower risk.
Before the introduction of ART, wasting and/or weight loss were among the most frequent AIDS-defining conditions and strong predictors of death and disease.
Multiple factors contribute to HIV-related weight loss. The inability to digest and absorb food nutrients (gastrointestinal malabsorption), often indicated by diarrhoea, is a suggested major cause.
The authors cite the Nutrition for Health Living (NFHL), a longitudinal study from 1995 to 2005 of HIV-infected adults in the greater Boston area of the United States showing that even in the era of ART malabsorption still contributes to weight loss.
In addition a decreased intake of calories due to neurological and/or psychiatric problems as well as oral symptoms making eating and/or swallowing difficult contribute to and/or exacerbate mal-absorption.
In spite of the positive benefits of ART, weight loss is still an independent predictor of HIV disease progression and death.
The authors note that most published studies have focused on resource-rich settings with small sample sizes; few have looked at predictors of weight change after starting ART with some only looking at factors contributing to weight gain.
So the authors chose to look at those factors predicting significant weight loss after starting ART in a large cohort of HIV-infected adults in a resource-poor setting in the short-term (three months) and long-term.
From November 2004 to December 2009 21,987 HIV-infected adults started ART and were followed for at least three months in US PEPFAR supported HIV care and treatment clinics in Dar es Salaam, Tanzania. After excluding those who had previously been on ART, pregnant women and those without body mass index (BMI) or weight data at the start of ART the final sample size was 18,956.
BMI was defined as: below 18.5kg/m2 -underweight; between 18.5 and below 25.0 kg/m2-normal weight; between 25.0 kg/m2 and below 30.0 kg/m2 –overweight; and equal to or over 30.0 kg/m2-obese.
Possible predictors of weight loss at the start of ART included: age; gender; CD4 cell count; haemoglobin level; WHO clinical HIV stage; three districts of Dar es Salaam as a proxy for socio-economic status (SES): high (Kinondoni), medium (Ilala) and low (Temeke) SES areas, calendar year and ART regimen.
The median age of the cohort was 36 years (IQR: 31-43) with the majority female (67%).
The proportion of those underweight, normal weight and overweight/obese at the start of ART was 28%, 57% and 15%, respectively. 55% had a CD cell count under 200 cells/mm3 and 85% were at WHO clinical stage 3 or 4.
The median weight change among those underweight was 4.0 kg (IQR: 1.0-7.0) significantly higher (p<0.01) than weight change among those of normal weight and overweight/obese.
Close to 50% of underweight patients gained more than 10% of their baseline weight compared to 19% and 8% among those of normal weight and overweight/obese, respectively.
The authors note other studies have reported similar findings in resource-poor settings.
Over a median follow-up period of 10 months (IQR: 4-20 months) a total of 5,889 (31%) experienced an initial significant weight loss after starting ART.
The authors note patients of middle-age (30-49) were less likely to have a significant weight loss as were those living in the highest SES district possibly because of better socio-economic conditions and so better access to nutrition rich diets.
The authors found low haemoglobin levels (an indicator for anaemia) at the start of ART were linked to a risk for significant weight loss at three months for all except those underweight.
They suggest a higher BMI at the start of ART may mean an absence of other illnesses so making the effect of anaemia on weight loss more pronounced.
Anaemia, they add, has been found to be an independent predicator of weight loss and death in HIV-infected individuals. And, in resource-poor settings it is associated with tuberculosis and malnutrition among other conditions.
As in other studies CD4 cell count was an independent predictor of long-term significant weight loss. When CD4 cell counts were over 350 cells/mm3 the association with weight loss decreased.
One of the study’s strengths is the inclusion of a large, diverse population in a resource-poor setting.
Limitations include no data on viral load, food availability or nutrient intake.
The authors conclude while body weight increased steadily after the start of ART close to 10% lost more than or equal to 5% bodyweight at three months. They caution “even in the era of ART, physicians still need to remain vigilant about patients’ weight. Our findings on the effect of socio-demographics, symptoms and diseases, biomedical indicators in relations to weight loss provide important information that has significant practical implications.”
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